usfdУльтразвуковая и функциональная диагностикаUltrasound & Functional Diagnostics1607-07712408-9494Vidar Ltd.usfd-249Research ArticleУльтразвуковая диагностика заболеваний сердца и сосудовCardiovascular UltrasoundУльтразвуковая оценка морфометрических показателей, систолической и диастолической функции левого желудочка сердца у детей с β-талассемиейEchocardiographic Assessment of Left Ventricular Morphometry and Systolic and Diastolic Function in Children with β-thalassemiaСугакАнна БорисовнаSugakA. B.sugak08@mail.ruНиколаеваГ. Н.NikolaevaG. N.noemail@neicon.ruФеоктистоваЕ. В.FeoktistovaE. V.noemail@neicon.ruФГБУ “Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева” Министерства здравоохранения Российской ФедерацииРоссияDmitry Rogachev Federal Research Center of Pediatric Hematology, Oncology and ImmunologyRussian Federation201630032024044758Copyright © Сугак А.Б., Николаева Г.Н., Феоктистова Е.В., 20242024Сугак А.Б., Николаева Г.Н., Феоктистова Е.В.Sugak A.B., Nikolaeva G.N., Feoktistova E.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://usfd.vidar.ru/jour/article/view/249

Цель исследования - оценить возможности эхокардиографии в ранней диагностике изменений строения и функции левого желудочка у детей с β-талассемией. Эхокардиография с исследованием движения фиброзного кольца митрального клапана в режиме тканевой допплерографии была проведена 50 пациентам с Дталассемией и 47 условно здоровым детям от 2 до 16 лет. У пациентов с β-талассемией были достоверно выше конечно-систолический и конечно-диастолический диаметры левого желудочка, индексы конечно-систолического и конечно-диастолического объемов левого желудочка, индекс массы миокарда левого желудочка, диаметр левого предсердия, сердечный индекс, скорости трансмитрального кровотока (Е и А), диастолические скорости движения фиброзного кольца митрального клапана (е’ и а’) и отношение Е/е’ (P < 0,05 для всех сравнений). Фракция выброса левого желудочка была достоверно ниже по сравнению с контрольной группой (P < 0,05). Для повышения точности эхокардиографии в ранней диагностике нарушения функции сердца у пациентов с β-талассемией необходима разработка нормальных для β-талассемии референсных значений фракции выброса и фракции укорочения левого желудочка, а также показателей диастолической функции левого желудочка. Оценка строения и функции сердца должна выполняться в центрах, имеющих опыт работы с больными β-талассемией, и учитывать особенности гемодинамики при хронической анемии.

Aim of the study - early left ventricular morphometry and function changes assessment in children with β-thalassemia. Echocardiography including tissue Doppler imaging analysis of the diastolic velocities of the mitral annulus motion was done to 50 children with β-thalassemia and 47 healthy children from 2 to 16 years old. Patients with β-thalassemia had significantly higher left ventricular end-systolic and end-diastolic diameters, left ventricular end-systolic and end-diastolic volume indexes, left ventricular myocardial mass index, left atrial diameter, cardiac index, transmitral diastolic velocities (Е and А), diastolic velocities of the mitral annulus motion (е’ and а’), and ratio Е/е’ in compare with the control group (P < 0.05 for all comparisons). Left ventricular ejection fraction in children with β-thalassemia was significantly lower in compare with the control group (P < 0.05).

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The authors declare that there are no conflicts of interest present.