usfdУльтразвуковая и функциональная диагностикаUltrasound & Functional Diagnostics1607-07712408-9494Vidar Ltd.usfd-251Research ArticleОбзорыReviewsСравнительная характеристика ультразвуковых контрастных препаратов (обзор литературы)Comparison of Ultrasound Contrast Agents (Literature Review)ВасильевА. Ю.VasilievA. Yu.noemail@neicon.ruКапустинВ. В.KapustinV. V.noemail@neicon.ruВасильеваЮ. Н.VasilievaYu. N.noemail@neicon.ruШуминаЯна АндреевнаShuminaYa. A.yana.shu92@gmail.comФГБОУ ВО “Московский государственный медико-стоматологический университет имени А.И. Евдокимова” Министерства здравоохранения Российской ФедерацииРоссияA.I. Evdokimov Moscow State University of Medicine and DentistryRussian Federation201630032024047381Copyright © Васильев А.Ю., Капустин В.В., Васильева Ю.Н., Шумина Я.А., 20242024Васильев А.Ю., Капустин В.В., Васильева Ю.Н., Шумина Я.А.Vasiliev A.Y., Kapustin V.V., Vasilieva Y.N., Shumina Y.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://usfd.vidar.ru/jour/article/view/251

Представлены результаты сравнительного анализа ультразвуковых контрастных препаратов, применяющихся в разных странах. Обзор научного материала выполнен на основе данных российских и зарубежных исследователей за последние 10 лет. Описано применение ультразвуковых контрастных препаратов в клинической практике с диагностической и лечебной целями. Отмечены факторы, влияющие на выбор того или иного препарата.

Comparative analysis of ultrasound contrast agents used in different countries is presented. The review is based on the studies done over the past ten years. The application of ultrasound contrast agents in clinical practice for diagnostic and therapeutic purposes is described.

ультразвуковая диагностикаультразвуковые контрастные препаратыультразвуковое исследование с контрастным усилениемultrasound diagnosticsultrasound contrast agent (UCA)contrast-enhanced ultrasound (CEUS)ReferencesLencioni R. Enhancing the Role of Ultrasound with Contrast Agents. Pisa: Springer Science & Business Media, 2006. P. 3-12.Lencioni R. Enhancing the Role of Ultrasound with Contrast Agents. Pisa: Springer Science & Business Media, 2006. P. 3-12.Klein A.L., Asher C.R. Clinical Echo cardio graphy Review: a Self-Assessment Tool. Philapelphia: Lippincott Williams & Wilkins, 2011. 544 p.Klein A.L., Asher C.R. Clinical Echo cardio graphy Review: a Self-Assessment Tool. Philapelphia: Lippincott Williams & Wilkins, 2011. 544 p.Quaia E. Contrast Media in Ultrasonography: Basic Principles and Clinical Applications. Heidelberg: Springer Science & Business Media, 2005. P. 1-30.Quaia E. Contrast Media in Ultrasonography: Basic Principles and Clinical Applications. Heidelberg: Springer Science & Business Media, 2005. P. 1-30.Кардиология: Национальное руководство / Под ред. Ю.Н. Беленкова, Р.Г. Оганова. М.: ГЭОТАР-Медиа, 2010. 1 232 с.Кардиология: Национальное руководство / Под ред. Ю.Н. Беленкова, Р.Г. Оганова. М.: ГЭОТАР-Медиа, 2010. 1 232 с.Новиков Н.Е. Контрастно-усиленные ультразвуковые исследования. История развития и современные возможности // Russian Electronic Journal of Radiology. 2012. Т. 2. № 1. С. 20-28.Новиков Н.Е. Контрастно-усиленные ультразвуковые исследования. История развития и современные возможности // Russian Electronic Journal of Radiology. 2012. Т. 2. № 1. С. 20-28.СоноВью - контрастный препарат для ультразвуковой диагностики. Режим доступа: // http://бракко.рф/sonovue, свободный. Загл. с экрана.СоноВью - контрастный препарат для ультразвуковой диагностики. Режим доступа: // http://бракко.рф/sonovue, свободный. Загл. с экрана.Lumason (sulfur hexafluoride lipid-type A microspheres). Режим доступа: // http://imaging.bracco.com/us-en/lumason, свободный. Загл. с экрана.Lumason (sulfur hexafluoride lipid-type A microspheres). Режим доступа: // http://imaging.bracco.com/us-en/lumason, свободный. Загл. с экрана.Definity. Prescribing information. Режим доступа: // http://www.definityimaging.com/prescribing_info.html, свободный. Загл. с экрана.Definity. Prescribing information. Режим доступа: // http://www.definityimaging.com/prescribing_info.html, свободный. Загл. с экрана.Optison. Prescribing information. Режим доступа: // https://www.drugs.com/pro/optison.html, свобод ный. Загл. с экрана.Optison. Prescribing information. Режим доступа: // https://www.drugs.com/pro/optison.html, свобод ный. Загл. с экрана.CEUS Around the World // International Contrast Ultrasound Society (ICUS). Режим доступа: //http://www.icus-society.org/attachments/article/103/ICUS%20-%20CEUS%20Around%20the%20World.pdf, свободный. Загл. с экрана.CEUS Around the World // International Contrast Ultrasound Society (ICUS). Режим доступа: //http://www.icus-society.org/attachments/article/103/ICUS%20-%20CEUS%20Around%20the%20World.pdf, свободный. Загл. с экрана.Ultrasound Contrast Agent Sonazoid for Injection Released for Sale. Режим доступа: // http://www.daiichisankyo.com/media_investors/media_relations/press_releases/detail/005564.html, свободный. Загл. с экрана.Ultrasound Contrast Agent Sonazoid for Injection Released for Sale. Режим доступа: // http://www.daiichisankyo.com/media_investors/media_relations/press_releases/detail/005564.html, свободный. Загл. с экрана.Pellerito J., Polak J.F. Introduction to Vascular Ultrasonography. Philadelphia: Elsevier Health Sciences, 2012. 704 p.Pellerito J., Polak J.F. Introduction to Vascular Ultrasonography. Philadelphia: Elsevier Health Sciences, 2012. 704 p.Nakata N., Ohta T., Nishioka M., Takeyama H., Toriumi Y., Kato K., Nogi H., Kamio M., Fukuda K. Optimization of region of interest drawing for quantitative analysis: differentiation between benign and malignant breast lesions on contrastenhanced sonography // J. Ultrasound Med. 2015. V. 34. No. 11. P. 1969-1976.Nakata N., Ohta T., Nishioka M., Takeyama H., Toriumi Y., Kato K., Nogi H., Kamio M., Fukuda K. Optimization of region of interest drawing for quantitative analysis: differentiation between benign and malignant breast lesions on contrastenhanced sonography // J. Ultrasound Med. 2015. V. 34. No. 11. P. 1969-1976.Iezzi R., Petrone G., Ferrante A., Lauriola L., Vincenzoni C., la Torre M.F., Snider F., Rindi G., Bonomo L. The role of contrast-enhanced ultrasound (CEUS) in visualizing atherosclerotic carotid plaque vulnerability: Which injection protocol? Which scanning technique? // Eur. J. Radiol. 2015. V. 84. No. 5. P. 865-871.Iezzi R., Petrone G., Ferrante A., Lauriola L., Vincenzoni C., la Torre M.F., Snider F., Rindi G., Bonomo L. The role of contrast-enhanced ultrasound (CEUS) in visualizing atherosclerotic carotid plaque vulnerability: Which injection protocol? Which scanning technique? // Eur. J. Radiol. 2015. V. 84. No. 5. P. 865-871.Bertolotto M., Catalano O. Contrast-enhanced ultrasound: past, present, and future // Ultrasound Clin. 2009. V. 4. No. 3. P. 339-367.Bertolotto M., Catalano O. Contrast-enhanced ultrasound: past, present, and future // Ultrasound Clin. 2009. V. 4. No. 3. P. 339-367.Wang Y., Yan K., Fan Z., Sun L., Wu W., Yang W. Contrast-enhanced ultrasonography of pancreatic carcinoma: correlation with pathologic findings // Ultrasound Med Biol. 2008. V. 42. No. 4. P. 891-898.Wang Y., Yan K., Fan Z., Sun L., Wu W., Yang W. Contrast-enhanced ultrasonography of pancreatic carcinoma: correlation with pathologic findings // Ultrasound Med Biol. 2008. V. 42. No. 4. P. 891-898.Liu H., Jiang Y., Dai Q., Zhu Q., Wang L., Zhang J., Yang Q. Differentiation of benign and malignant ub-1-cm breast lesions using contrast-enhanced sonography // J. Ultrasound Med. 2015. V. 34. No. 1. P. 117-123.Liu H., Jiang Y., Dai Q., Zhu Q., Wang L., Zhang J., Yang Q. Differentiation of benign and malignant ub-1-cm breast lesions using contrast-enhanced sonography // J. Ultrasound Med. 2015. V. 34. No. 1. P. 117-123.Hoyt K., Umphrey H., Lockhart M., Robbin M., Forero-Torres A. Ultrasound imaging of breast tumor perfusion and neovascular morphology //Ultrasound Med. Biol. 2015. V. 41. No. 9. P. 2292-2302.Hoyt K., Umphrey H., Lockhart M., Robbin M., Forero-Torres A. Ultrasound imaging of breast tumor perfusion and neovascular morphology //Ultrasound Med. Biol. 2015. V. 41. No. 9. P. 2292-2302.Hu Q., Wang X.Y., Zhu S.Y., Kang L.K., Xiao Y.J., Zheng H.Y. Meta-analysis of contrast-enhanced ultrasound for the differentiation of benign and malignant breast lesions // Acta Radiol. 2015. V. 56. No. 1. P. 25-33.Hu Q., Wang X.Y., Zhu S.Y., Kang L.K., Xiao Y.J., Zheng H.Y. Meta-analysis of contrast-enhanced ultrasound for the differentiation of benign and malignant breast lesions // Acta Radiol. 2015. V. 56. No. 1. P. 25-33.Miyamoto Y., Ito T., Takada E., Omoto K., Hirai T., Moriyasu F. Efficacy of sonazoid (perflubutane) for contrast-enhanced ultrasound in the differentiation of focal breast lesions: phase 3 multicenter clinical trial // Am. J. Roentgenol. 2014. V. 202. No. 4. P. 400-407.Miyamoto Y., Ito T., Takada E., Omoto K., Hirai T., Moriyasu F. Efficacy of sonazoid (perflubutane) for contrast-enhanced ultrasound in the differentiation of focal breast lesions: phase 3 multicenter clinical trial // Am. J. Roentgenol. 2014. V. 202. No. 4. P. 400-407.Dahibawkar M., Forsberg M.A., Gupta A., Jaffe S., Dulin K., Eisenbrey J.R., Halldorsdottir V.G., Forsberg A.I., Dave J.K., Marshall A., Machado P., Fox T.B., Liu J.B., Forsberg F. High and low frequency subharmonic imaging of angiogenesis in a murine breast cancer model // Ultrasonics. 2015. V. 62. No. 8. P. 50-55.Dahibawkar M., Forsberg M.A., Gupta A., Jaffe S., Dulin K., Eisenbrey J.R., Halldorsdottir V.G., Forsberg A.I., Dave J.K., Marshall A., Machado P., Fox T.B., Liu J.B., Forsberg F. High and low frequency subharmonic imaging of angiogenesis in a murine breast cancer model // Ultrasonics. 2015. V. 62. No. 8. P. 50-55.Kim Y.S., Rubio V., Qi J., Xia R., Shi Z.Z., Peterson L., Tung C.H., O'Neill B.E. Cancer treatment using an optically inert Rose Bengal derivative combined with pulsed focused ultrasound // J. Control. Release. 2011. V. 156. No. 3. P. 315-322.Kim Y.S., Rubio V., Qi J., Xia R., Shi Z.Z., Peterson L., Tung C.H., O'Neill B.E. Cancer treatment using an optically inert Rose Bengal derivative combined with pulsed focused ultrasound // J. Control. Release. 2011. V. 156. No. 3. P. 315-322.Abel M., Teoh W.C., Leen E. Contrast evaluation of liver masses // Ultrasound Clin. 2014. V. 9. No. 4. P. 605-623.Abel M., Teoh W.C., Leen E. Contrast evaluation of liver masses // Ultrasound Clin. 2014. V. 9. No. 4. P. 605-623.Guo L.H., Xu H.X. Contrast-Enhanced Ultrasound in the Diagnosis of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: Controversy over the ASSLD Guideline // Biomed Res. Int. 2015: 349172. Doi: 10.1155/2015/3491722015.Guo L.H., Xu H.X. Contrast-Enhanced Ultrasound in the Diagnosis of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: Controversy over the ASSLD Guideline // Biomed Res. Int. 2015: 349172. Doi: 10.1155/2015/3491722015.Claudon M., Dietrich C.F., Choi B.I., Cosgrove D.O., Kudo M., Nolsoe C.P., Piscaglia F., Wilson S.R., Barr R.G., Chammas M.C., Chaubal N.G., Chen M.H., Clevert D.A., Correas J.M., Ding H., Forsberg F., Fowlkes J.B., Gibson R.N., Goldberg B.B., Lassau N., Leen E.L.S., Mattrey R.F., Mori yasu F., Solbiati L., Weskott H.P., Xu H.X. Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver - update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS // Ultraschall Med. 2013. V. 34. No. 1. P. 11-29.Claudon M., Dietrich C.F., Choi B.I., Cosgrove D.O., Kudo M., Nolsoe C.P., Piscaglia F., Wilson S.R., Barr R.G., Chammas M.C., Chaubal N.G., Chen M.H., Clevert D.A., Correas J.M., Ding H., Forsberg F., Fowlkes J.B., Gibson R.N., Goldberg B.B., Lassau N., Leen E.L.S., Mattrey R.F., Mori yasu F., Solbiati L., Weskott H.P., Xu H.X. Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver - update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS // Ultraschall Med. 2013. V. 34. No. 1. P. 11-29.Von Herbay A., Barreiros A.P., Ignee A., Westendorff J., Gregor M., Galle P.R., Dietrich C. Contrast-enhanced ultrasonography with SonoVue: differentiation between benign and malignant lesions of the spleen // J. Ultrasound Med. 2009. V. 28. No. 4. P. 421-434.Von Herbay A., Barreiros A.P., Ignee A., Westendorff J., Gregor M., Galle P.R., Dietrich C. Contrast-enhanced ultrasonography with SonoVue: differentiation between benign and malignant lesions of the spleen // J. Ultrasound Med. 2009. V. 28. No. 4. P. 421-434.Kanemoto H., Onho K., Takahashi M., Fujino Y., Tsujimoto H. Vascular and Kupffer imaging of canine liver and spleen using the new contrast agent Sonazoid // J. Vet. Med. Sci. 2008. V. 70. No. 11. P. 1265-1268.Kanemoto H., Onho K., Takahashi M., Fujino Y., Tsujimoto H. Vascular and Kupffer imaging of canine liver and spleen using the new contrast agent Sonazoid // J. Vet. Med. Sci. 2008. V. 70. No. 11. P. 1265-1268.Mishima M., Toh U., Iwakuma N., Takenaka M., Furukawa M., Akagi Y. Evaluation of contrast Sonazoid-enhanced ultrasonography for the detection of hepatic metastases in breast cancer // Breast Cancer. 2014. V. 23. No. 2. P. 231-241.Mishima M., Toh U., Iwakuma N., Takenaka M., Furukawa M., Akagi Y. Evaluation of contrast Sonazoid-enhanced ultrasonography for the detection of hepatic metastases in breast cancer // Breast Cancer. 2014. V. 23. No. 2. P. 231-241.Wilson S.R., Burns P.N. Microbubble-enhanced US in body imaging: what role? // Radiology. 2010. V. 257. No. 1. P. 24-39.Wilson S.R., Burns P.N. Microbubble-enhanced US in body imaging: what role? // Radiology. 2010. V. 257. No. 1. P. 24-39.Bialecki M., Bialecka A., Laskowska K., Klopocka M., Liebert A., Lemanowicz A., Serafin Z. Contrast-enhanced ultrasonography for the determination of Crohn’s disease activity - preliminary experience // Pol. J. Radiol. 2014. V. 79. No. 1. P. 70-74.Bialecki M., Bialecka A., Laskowska K., Klopocka M., Liebert A., Lemanowicz A., Serafin Z. Contrast-enhanced ultrasonography for the determination of Crohn’s disease activity - preliminary experience // Pol. J. Radiol. 2014. V. 79. No. 1. P. 70-74.Matsubara H., Itoh A., Kawashima H., Kasugai T., Ohno E., Ishikawa T., Itoh Y., Nakamura Y., Hiramatsu T., Nakamura M., Miyahara R., Ohmiya N., Ishigami M., Katano Y., Goto H., Hirooka Y. Dynamic quantitative evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic diseases // Pancreas. 2011. V. 40. No. 7. P. 1073-1079.Matsubara H., Itoh A., Kawashima H., Kasugai T., Ohno E., Ishikawa T., Itoh Y., Nakamura Y., Hiramatsu T., Nakamura M., Miyahara R., Ohmiya N., Ishigami M., Katano Y., Goto H., Hirooka Y. Dynamic quantitative evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic diseases // Pancreas. 2011. V. 40. No. 7. P. 1073-1079.Ang T.L., Teo E.K., Ang D., Kwek A.B., Fock K.M. A pilot study of contrast harmonic endosonography using DEFINITYTM in the evaluation of suspected pancreatic and peri-ampullary malignancies // J. Interv. Gastroenterol. 2011. V. 1. No. 4. P. 160-165.Ang T.L., Teo E.K., Ang D., Kwek A.B., Fock K.M. A pilot study of contrast harmonic endosonography using DEFINITYTM in the evaluation of suspected pancreatic and peri-ampullary malignancies // J. Interv. Gastroenterol. 2011. V. 1. No. 4. P. 160-165.Kobayashi G., Fujita N., Noda Y., Ito K., Horaguchi J., Koshida S., Kanno Y., Ogawa T., Masu K., Michikawa Y. Vascular image in autoimmune pancrea titis by contrast-enhanced color-Doppler endoscopic ultrasonography: comparison with pancreatic cancer // Endosc. Ultrasound. 2014. V. 3. Suppl. 1. P. S13.Kobayashi G., Fujita N., Noda Y., Ito K., Horaguchi J., Koshida S., Kanno Y., Ogawa T., Masu K., Michikawa Y. Vascular image in autoimmune pancrea titis by contrast-enhanced color-Doppler endoscopic ultrasonography: comparison with pancreatic cancer // Endosc. Ultrasound. 2014. V. 3. Suppl. 1. P. S13.Hocke M., Cui X.W., Domagk D., Ignee A., Dietrich C.F. Pancreatic cystic lesions: the value of contrast-enhanced endoscopic ultrasound to influence the clinical pathway // Endosc. Ultrasound. 2014. V. 3. No. 2. P. 123-130.Hocke M., Cui X.W., Domagk D., Ignee A., Dietrich C.F. Pancreatic cystic lesions: the value of contrast-enhanced endoscopic ultrasound to influence the clinical pathway // Endosc. Ultrasound. 2014. V. 3. No. 2. P. 123-130.Miele V., Piccolo C.L., Galluzzo M., Ianniello S., Sessa B., Trinci M. Contrast-enhanced ultrasound (CEUS) in blunt abdominal trauma // Br. J. Radiol. 2015. V. 89. No. 5. P. 1-15.Miele V., Piccolo C.L., Galluzzo M., Ianniello S., Sessa B., Trinci M. Contrast-enhanced ultrasound (CEUS) in blunt abdominal trauma // Br. J. Radiol. 2015. V. 89. No. 5. P. 1-15.Barr R.G., Peterson C., Hindi A. Evaluation of indeterminate renal masses with contrast-enhanced US: a diagnostic performance study // Radiology. 2014. V. 271. No. 1. P. 133-142.Barr R.G., Peterson C., Hindi A. Evaluation of indeterminate renal masses with contrast-enhanced US: a diagnostic performance study // Radiology. 2014. V. 271. No. 1. P. 133-142.Maxim A.R., Badea R., Tamas A., Traila A. Contrast-enhanced ultrasound in ovarian tumors - diagnostic parameters: method presentation and initial experience // Clujul Medical. 2013. V. 86. No. 1. P. 31-35.Maxim A.R., Badea R., Tamas A., Traila A. Contrast-enhanced ultrasound in ovarian tumors - diagnostic parameters: method presentation and initial experience // Clujul Medical. 2013. V. 86. No. 1. P. 31-35.Fleischer A.C., Lyshchik A., Andreotti R.F., Hwang M., Jones H.W. 3rd, Fishman D.A. Advances in sonographic detection of ovarian cancer: depiction of tumor neovascularity with microbubbles // Am. J. Roentgenol. 2010. V. 194. No. 2. P. 343-348.Fleischer A.C., Lyshchik A., Andreotti R.F., Hwang M., Jones H.W. 3rd, Fishman D.A. Advances in sonographic detection of ovarian cancer: depiction of tumor neovascularity with microbubbles // Am. J. Roentgenol. 2010. V. 194. No. 2. P. 343-348.Yan L., Wang A., Bai R., Shang W., Zhao Y., Wang W., Guo W. Application of SonoVue combined with three-dimensional color power angiography in the diagnosis and prognosis evaluation of intrauterine adhesion // Eur. J. Obstet. Gynecol. Reprod. Biol. 2016. V. 198. P. 68-72.Yan L., Wang A., Bai R., Shang W., Zhao Y., Wang W., Guo W. Application of SonoVue combined with three-dimensional color power angiography in the diagnosis and prognosis evaluation of intrauterine adhesion // Eur. J. Obstet. Gynecol. Reprod. Biol. 2016. V. 198. P. 68-72.Isern J., Pessarrodona A., Rodriguez J., Vallejo E., Gimenez N., Cassado J., De Marco J.A., Pedrerol A. Using microbubble sonographic contrast agent to enhance the effect of high intensity focused ultrasound for the treatment of uterine fibroids // Ultrason. Sonochem. 2015. V. 27. No. 6. P. 688-693.Isern J., Pessarrodona A., Rodriguez J., Vallejo E., Gimenez N., Cassado J., De Marco J.A., Pedrerol A. Using microbubble sonographic contrast agent to enhance the effect of high intensity focused ultrasound for the treatment of uterine fibroids // Ultrason. Sonochem. 2015. V. 27. No. 6. P. 688-693.Gao Y., Liao X.H., Lu L., Wang L., Ma Y., Qin H.Z., Yan X., Guo P. Contrast-enhanced transrectal ultrasonography for the detection of diffuse prostate cancer // Clin. Radiol. 2016. V. 71. No. 3. P. 258-264.Gao Y., Liao X.H., Lu L., Wang L., Ma Y., Qin H.Z., Yan X., Guo P. Contrast-enhanced transrectal ultrasonography for the detection of diffuse prostate cancer // Clin. Radiol. 2016. V. 71. No. 3. P. 258-264.Thomas Jefferson University. Contrast Ultrasound Detection of Sentinel Lymph Nodes // A service of the U.S. National Institutes of Health. Режим доступа: // https://clinicaltrials.gov/ct2/show/NCT02652923, свободный. Загл. с экрана.Thomas Jefferson University. Contrast Ultrasound Detection of Sentinel Lymph Nodes // A service of the U.S. National Institutes of Health. Режим доступа: // https://clinicaltrials.gov/ct2/show/NCT02652923, свободный. Загл. с экрана.Hua X., Zhu L.P., Zhong H., Xue Y.F., Chen Z.H. Effects of diagnostic contrast-enhanced ultrasound on permeability of placental barrier: a primary study // Placenta. 2009. V. 30. No. 9. P. 780-784.Hua X., Zhu L.P., Zhong H., Xue Y.F., Chen Z.H. Effects of diagnostic contrast-enhanced ultrasound on permeability of placental barrier: a primary study // Placenta. 2009. V. 30. No. 9. P. 780-784.

The authors declare that there are no conflicts of interest present.