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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">usfd</journal-id><journal-title-group><journal-title xml:lang="ru">Ультразвуковая и функциональная диагностика</journal-title><trans-title-group xml:lang="en"><trans-title>Ultrasound &amp; Functional Diagnostics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0771</issn><issn pub-type="epub">2408-9494</issn><publisher><publisher-name>Vidar Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0771-2023-4-67-95</article-id><article-id custom-type="elpub" pub-id-type="custom">usfd-70</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Ультразвуковая диагностика в акушерстве и гинекологии</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Obstetrics and Gynecology Ultrasound</subject></subj-group></article-categories><title-group><article-title>Маркеры неблагоприятного исхода беременности при ультразвуковом исследовании в эмбриональном периоде: литературный обзор и собственные клинические наблюдения</article-title><trans-title-group xml:lang="en"><trans-title>Ultrasound markers of adverse pregnancy outcomes  in embryonal period: literature review and own clinical cases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-2412-628X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тимакина</surname><given-names>Д. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Timakina</surname><given-names>D. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тимакина Дарья Николаевна – врач ультразвуковой диагностики ООО “Хороший доктор”, Москва.</p></bio><bio xml:lang="en"><p>Darya N. Timakina –ultrasound diagnostic doctor, LLC “Good Doctor”, Moscow.</p></bio><email xlink:type="simple">drtimakina@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8295-768X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Буланов</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Bulanov</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Буланов Михаил Николаевич – доктор мед. наук, заведующий отделением ультразвуковой диагностики ГБУЗ ВО “Областная клиническая больница”, Владимир; профессор кафедры внутренних болезней Института медицинского образования ФГБОУ ВО “Новгородский государственный университет имени Ярослава Мудрого”, Великий Новгород. Главный внештатный специалист по ультразвуковой диагностикt Минздрава Владимирской области. </p></bio><bio xml:lang="en"><p>Mikhail N. Bulanov – Doct. of Sci. (Med.), Head of Ultrasound Diagnostics Department, Regional Clinical Hospital, Vladimir; Professor, Division of Internal Medicine, Institute of Medical Education, Yaroslav-the-Wise Novgorod State University, Veliky Novgorod.</p></bio><email xlink:type="simple">doctorbulanov@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ООО “Хороший доктор”; 107076 Москва, ул. Краснобогатырская, д. 90, с. 2, Российская Федерация<country>Россия</country></aff><aff xml:lang="en">Clinic Good Doctor; 90, bld. 2, Krasnobogatyrskaya str., Moscow 107076, Russian Federation<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГБУЗ Владимирской области “Областная клиническая больница”; 600023 Владимир, Судогодское шоссе, д. 41, Российская Федерация&#13;
&#13;
ФГБОУ ВПО “Новгородский государственный университет имени Ярослава Мудрого”; 173003 Великий Новгород, ул. Большая Санкт-Петербургская, д. 41, Российская Федерация<country>Россия</country></aff><aff xml:lang="en">Regional Clinical Hospital; 21, Sudogodskoye shosse, Vladimir 600023, Russian Federation&#13;
Yaroslav-the-Wise Novgorod State University; 41, Bolshaya St. Petersburgskaya str., Veliky Novgorod 173003, Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>23</day><month>03</month><year>2024</year></pub-date><volume>0</volume><issue>4</issue><fpage>67</fpage><lpage>95</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Тимакина Д.Н., Буланов М.Н., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Тимакина Д.Н., Буланов М.Н.</copyright-holder><copyright-holder xml:lang="en">Timakina D.N., Bulanov M.N.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://usfd.vidar.ru/jour/article/view/70">https://usfd.vidar.ru/jour/article/view/70</self-uri><abstract><p> </p><p>Настоящий обзор выполнен с целью поиска и описания всех известных на сегодня маркеров неблагоприятного исхода беременности, наблюдаемых при ультразвуковом исследовании (УЗИ) в эмбриональном периоде. Обзор проиллюстрирован многочисленными собственными эхограммами, отражающими конкретные клинические наблюдения. С учетом опыта авторов все приведенные в обзоре ультразвуковые признаки можно использовать в качестве предикторов (маркеров) неблагоприятного исхода беременности на ранних сроках. При этом, с нашей точки зрения, маркеры правильно будет разделить на две группы, которые мы условно назвали “первичные маркеры” и “динамические маркеры”. “Первичные маркеры” обнаруживаются при первичном УЗИ. После их визуализации целесообразно через 7–10 дней назначить контрольное УЗИ с целью подтверждения развивающейся беременности или постановки диагноза неразвивающейся беременности. В ходе этого динамического наблюдения допустимо использование “динамических маркеров”. Некоторые “динамические маркеры” можно использовать в ходе более короткого динамического наблюдения, когда необходимо сделать вывод о прогнозе за более короткий период наблюдения, чем 7–10 дней. В общей сложности в обзоре описаны 22 маркера неблагоприятного исхода беременности, которые могут наблюдаться при УЗИ в эмбриональном периоде. Это особенности ультразвукового изображения плодного яйца, желточного мешка, размера эмбриона, сердцебиения эмбриона, амниотической полости. УЗИ в ранние сроки беременности не является обязательным. Однако на практике ввиду множества объективных и субъективных причин почти каждая беременная проходит УЗИ в ранние сроки беременности. Именно поэтому уже в первые дни беременности ей должен быть обеспечен исключительно высокопрофессиональный подход со стороны врача ультразвуковой диагностики, который сможет оценить риски и прогноз для благополучного вынашивания беременности и рождения здорового ребенка. Авторы обзора подчеркивают, что оценка ультразвуковых маркеров неблагоприятного исхода беременности должна проводиться со строжайшим соблюдением медицинской этики, деонтологии, а также врачебной тайны.</p></abstract><trans-abstract xml:lang="en"><p>A goal of the review was to search and describe all currently known prenatal ultrasound markers of adverse pregnancy outcomes. The review is instantiated by multiple ultrasound images of own clinical cases. Taking into account the authors wide experience, it is possible to use all of presented ultrasound signs as predictors (markers) of an adverse pregnancy outcome in the early stages. From our point of view, it is reasonable to divide the markers into two groups, “primary markers” and “dynamic markers”. In the case of “Primary markers” revealing on initial ultrasound, it is reasonable to perform control ultrasound in 7–10 days to confirm the viable pregnancy or missed miscarriage.  The “Dynamic markers” can be used on control ultrasound, and some of them may be used in shorter dynamic period when there is a need to predict the outcome earlier than 7-10 days. Generally, the review describes 22 early pregnancy ultrasound markers of adverse pregnancy outcome. These are imaging features of the gestational sac, yolk sac, embryo size, embryo heartbeat, and amnion. Early pregnancy ultrasound is not mandatory, but in a real-case scenario, almost all women undergoes ultrasound on early stage of pregnancy in objective or subjective causes. Therefore, in the first days of pregnancy, women should receive a highly professional diagnostic by a physician, able to assess the risks and prognosis of pregnancy outcome. The authors of the review particularly notes that the assessment of ultrasound markers of adverse pregnancy outcomes must be carried out with the strictest adherence to the medical ethics, deontology, and medical privacy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ультразвуковая диагностика</kwd><kwd>ультразвуковые маркеры</kwd><kwd>ранние сроки беременности</kwd><kwd>эмбриональный период</kwd><kwd>неразвивающаяся беременность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ultrasound</kwd><kwd>ultrasound markers</kwd><kwd>early pregnancy</kwd><kwd>embryonal period</kwd><kwd>missed miscarriage</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology. ACOG Practice Bulletin No. 200: Early Pregnancy Loss. 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