Left ventricular local longitudinal systolic strain magnitude in prediction of risk of cardiovascular events in patients after acute coronary syndrome

The aim of the study was to investigate the influence of left ventricular local longitudinal systolic strain magnitude on risk of cardiovascular events in patients after acute coronary syndrome. 146 patients with verified acute coronary syndrome were examined. According to major adverse cardiac events (MACE) appearance in the post-hospital follow-up period they were divided into two groups. 45 patients with MACE were included in the 1st group, 101 patients without MACE - in the 2nd one. The follow-up median was 47 months, (25-75th percentiles - 32-60 months). Longitudinal systolic strain of anterior septal, inferior, and inferior septal walls of left ventricle was evaluated at apical views by two-dimensional speckle-tracking echocardiography. According to the Kaplan-Mayer survival analysis, risk of cardiovascular events for 5 years after acute coronary syndrome may be assessed with the use of initial values of left ventricular inferior and inferior septal walls longitudinal systolic strain (P = 0.01 and P = 0.002, respectively). If value of inferior and inferior septal walls longitudinal systolic strain decreases by less than 14%, the probability of MACE in patients 5 years after acute coronary syndrome increases by more than 20 and 30%, respectively. Thus, reduced longitudinal systolic strain of left ventricular inferior and inferior septal walls in patients with acute coronary syndrome is an adverse prognostic factor of increased risk of cardiovascular events during the long-term follow-up.

ультразвуковое исследование сердца (эхокардиография), острый коронарный синдром, продольная деформация, сердечно-сосудистый риск, кривые выживаемости Каплана-Майера, echocardiography, acute coronary syndrome, longitudinal strain, cardiovascular risk, Kaplan Meier survival curves

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