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Metastatic peripheral lymph nodes in cutaneous malignant melanoma: role of shear wave elastography

https://doi.org/10.24835/1607-0771-2017-6-25-35

Abstract

From January to August 2017, lymph nodes ultrasound examination was performed to 51 patients (23 men and 28 women) (23-86 years old) with a histologically verified cutaneous malignant melanoma diagnosis. In all patients metastasis in lymph nodes of different localization (axillary, cervical, and inguinal lymph nodes) were suspected according to gray-scale and Doppler ultrasound. All patients were examined using ultrasound system Aplio 500 (Toshiba, Japan) with linear transducer 7-18 MHz. The first group included 21 patients with confirmed metastatic lymph nodes, the second - 30 patients with hyperplasia of lymphoid reticular tissue. Young’s modulus values for metastatic lymph nodes were 101.8 kPa (median), 14.0-164.5 kPa (2.5-97.5th percentiles), for hyperplastic lymph nodes - 15.0 kPa, 7.2-56.8 kPa, respectively. Significant differences in Young’s modulus values between metastatic and hyperplastic lymph nodes in patients with cutaneous malignant melanoma were revealed (P < 0.0001). Young’s modulus values in metastatic lymph nodes were not correlated with Clark level of melanoma invasion, nor with the localization of metastases (axillary, cervical, and inguinal lymph nodes). The best Young’s module cut-off value for metastatic lymph nodes detection in case of skin melanoma was 22.7 kPa (sensitivity - 86%, specificity - 77%, AUC - 0,916).

About the Authors

O. V. Kostash
Moscow City Oncology Hospital No. 62
Russian Federation


Yu. V. Kabin
Moscow City Oncology Hospital No. 62
Russian Federation


N. A. Smekhov
Clinical Diagnostic Center No. 4
Russian Federation


V. V. Kapustin
Moscow City Oncology Hospital No. 62
Russian Federation


A. I. Gromov
Moscow Research and Practical Centre of Medical Radiology
Russian Federation


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Review

For citations:


Kostash O.V., Kabin Yu.V., Smekhov N.A., Kapustin V.V., Gromov A.I. Metastatic peripheral lymph nodes in cutaneous malignant melanoma: role of shear wave elastography. Ultrasound & Functional Diagnostics. 2017;(6):25-35. (In Russ.) https://doi.org/10.24835/1607-0771-2017-6-25-35

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ISSN 1607-0771 (Print)
ISSN 2408-9494 (Online)