ARFI-elastography in Differential Diagnosis of Solid Lesions in Children

Aim of the study was to assess value of ARFI-elastography in differential diagnosis of benign and malignant solid lesions of different localization in children. 121 children aged from 1 up to 216 months (45 children with neuroblastoma, 14 - with hepatoblastoma, 14 - with liver hemangioma, 14 - with nephroblastoma, 7 - with sarcoma of different localization, 15 - with other different benign lesions, 12 - with other different malignant lesions) were examined. All children underwent ARFI-elastography of tumors with stiffness value (median) assessment according to shear wave speed 10 times measurements in the lesion. Values of shear wave speed were calculated for each type of lesions. There was not any significant difference between the stiffness of the liver hemangioma (2.04 m/s (median), 1.74-2.32 m/s (25^th-75^thpercentiles)) and hepatoblastoma (1.85, 1.60-2.27 m/s) (P = 0.37). The same was noticed in the group of patients with ganglioneuroma (1.02, 0.93-1.95 m/s) and neuroblastoma (1.77,1.18-2.14 m/s) (P = 0.28). There was not any significant difference between the group of patients with benign (1.97, 1.20-2.77 m/s) and malignant (1.72, 1.20-2.06 m/s) lesions as well (P = 0.23). The shear wave speed cut-off value for differentiation between benign and malignant lesions was equal to 1.93 m/s with sensitivity - 0.696, specificity - 0.586, AUC - 0.588. It did not allow recommending ARFI-elastography for the daily use.

точечная эластография сдвиговой волной, фокусированный акустический импульс (ARFI), ARFI-эластография, доброкачественные и злокачественные образования, гемангиома, гепатобластома, ганглионеврома, нейробластома, дети, point shear wave elastography, acoustic radiation force impulse elastography (ARFI-elastography), benign and malignant tumors, hemangioma, hepatoblastoma, ganglioneuroma, neuroblastoma, children

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