Preview

Ultrasound & Functional Diagnostics

Advanced search

Ultrasound in Assessment of Diabetic Macroangiopathy and Microangiopathy in Patients with Type 2 Diabetes Mellitus

Abstract

Aim of the study was to assess Doppler parameters in renal and central retinal arteries in comparison with a common carotid artery intima-media characteristics using color and pulse wave Doppler. These parameters were studied in 100 patients with type 2 diabetes mellitus and in 20 healthy volunteers. Abnormal lamination and solitary hyperechoic elements within the vascular wall were presented as ultrasound features of the diabetic (metabolic) macroangiopathy. Ultrasound hallmarks of the diabetic microangiopathy in patients with type 2 diabetes mellitus were characterized by reduction of the blood flow velocities and increase of peripheral resistance indices in renal and central retinal arteries. Diabetic microangiopathy causes similar changes of the peripheral resistance indices in renal and central retinal arteries. Common carotid artery intima-media thickening is higher than peripheral resistance indices in renal and central retinal arteries increasing. Ultrasound signs of the diabetic macroangiopathy in common carotid artery have prognostic value for diabetic microangiopathy in renal and central retinal arteries.

About the Authors

D. A. Golovin
Pirogov Russian National Research Medical University; Medical Center “Vascular Clinic"
Russian Federation


S. Eh. Lelyuk
Medical Center “Vascular Clinic"; Russian Medical Academy of Postgraduate Education
Russian Federation


V. G. Lelyuk
Pirogov Russian National Research Medical University; Medical Center “Vascular Clinic"
Russian Federation


References

1. Анциферов М.Б., Волковой А.К., Комелягина Е.Ю. Поражение нижних конечностей у больных сахарным диабетом // Русский медицинский журнал. 2007. № 3. С. 1-7.

2. Балаболкин М.И., Клебанова Е.М., Креминская В.М. Патогенез ангиопатий при сахарном диабете // Сахарный диабет. 1999. № 2. С. 1-12.

3. Балаболкин М.И., Чурмантаева Г.Х. Частота возникновения макроангиопатий при сахарном диабете первого и второго типа // Хирургические заболевания и сахарный диабет. Сборник статей. 1989.С.18-22.

4. Ефимов А.С. Диабетические ангиопатии. М.: Медицина, 1989. 288 с.

5. Liu K.H., Chu W.C., Kong A.P. et al. Intrarenal arterial resistance is associated with microvascular complications in Chinese type 2 diabetic patients // Nephrol. Dial. Transplant. 2013. V. 28. No. 3. P.651-658.

6. Hamano K., Nitta A., Ohtake T., Kobayashi S. Associations of renal vascular resistance with albuminuria and other macroangiopathy in type 2 diabetic patients // Diabetes Care. 2008. V. 31. No. 9. P. 1853-1857.

7. Basturk T., Akcay M., Albayrak R. et al. Correlation between the resistive index values of renal and orbital arteries // Kidney Blood Press. Res. 2012. V. 35. No. 5. P. 332-339.

8. Miyamoto M., Kotani K., Okada K. et al. The correlation of common carotid arterial diameter with atherosclerosis and diabetic retinopathy in patients with type 2 diabetes mellitus // Acta Diabetol. 2012. V. 49. No. 1. P. 63-68.

9. Ito H., Komatsu Y., Mifune M. et al. The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study // Cardiovasc. Diabetol. 2010. V. 9. P. 18. Doi: 10.1186/1475-2840-9-18.

10. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. Изд. 2-е / Под ред. И.И. Дедова, М.В. Шестаковой. М.: Медиа Сфера, 2006. 104 с.

11. Чазова И.Е., Мычка В.Б. Метаболический синдром. М.: Медиа Медика, 2004. 168 с.

12. Лелюк В.Г., Лелюк С.Э. Ультразвуковая ангиология. Изд. 3-е. М.: Реальное время, 2007. 416 с.

13. Dybdahl H., Ledet T. Diabetic macroangiopathy. Quantitative histopathological studies of the extramural coronary arteries from type 2 (non-insulin-dependent) diabetic patients // Diabetologia. 1987. V. 30. No. 11. P. 882-886.

14. Стаут Р. Гормоны и атеросклероз / Пер. с англ. М.: Медицина, 1985. 240 с.

15. Janka H.U., Standl E. Hyperinsulinaemia as a possible risk factor of macrovascular disease in diabetes mellitus. An overview // Diabete Metab. 1987. V. 13. No. 3. P. 279-283.

16. King G.L. Cell biology as an approach to the study of the vascular complications of diabetes // Metabolism. 1985. V. 34. No. 12. Suppl. 1. P. 17-24.

17. Pfeifle B., Ditshuneit A. Effect of insulin on growth of cultured human arterial smooth muscle cells // Diabetologia. 1981. V. 20. No. 8. P. 155-158.

18. Stout R.W. The effect of insulin and glucose on sterol synthesis in cultured rat arterial smooth muscle cells // Atherosclerosis. 1977. V. 27. No. 3. P.271-278.

19. Stout R.W. Glucose inhibits replication of cultured human endothelial cells // Diabetologia. 1982. V. 23. No. 5. P. 436-439.

20. Porta M., La Selva M., Molinatti P., Molinatti G.M. Endothelial cell function in diabetic microangiopathy // Diabetologia. 1987. V. 30. No. 8. P. 601-609.

21. Dobrina A., Rossi F. Metabolic properties of freshly isolated bovine endothelial cells // Biochim. Biophys. Acta. 1983. V. 762. No. 2. P. 295-301.


Review

For citations:


Golovin D.A., Lelyuk S.E., Lelyuk V.G. Ultrasound in Assessment of Diabetic Macroangiopathy and Microangiopathy in Patients with Type 2 Diabetes Mellitus. Ultrasound & Functional Diagnostics. 2016;(3):72-81. (In Russ.)

Views: 155


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1607-0771 (Print)
ISSN 2408-9494 (Online)