Shear wave elastography assessment of liver stiffness in children with cystic fibrosis

Ultrasound elastography was done to 200 children without liver pathology in age from 3 to 18 years (control group) and 32 children with cystic fibrosis in age from 2 to 17 years (study group). Disease in 17 (53.1%) children with cystic fibrosis was regarded as moderate (the first subgroup) and in 15 (46.9%) children - as severe (the second subgroup) (assessment of disease severity was conducted on a scale of Shwachman-Brasfield in the modification of S.P. Rachinsky and N.I. Kapranov). All patients underwent gray-scale liver ultrasound examination, which was supplemented by twodimensional shear wave elastography (Aixplorer, Supersonic Imagine, France) using a broadband convex probe(1-6 MHz). The values of Young modulus were measured 10 times in different segments of the right and left liver lobes with subsequent averaging. In patients with cystic fibrosis only 9 (28.1%) children had Young modulus values not exceeding those in healthy children (as threshold maximum value of Emean in the control group (6.30 kPa) was used). In patients with cystic fibrosis values of Young modulus were significantly higher than in control group (Emean median - 6.50 and 5.00 kPa, interquartile range - 5.62-7.52 and 4.70-5.38 kPa, respectively) (P < 0.001). In the subgroup with moderate cystic fibrosis Young modulus values were significantly lower compared with the subgroup with severe cystic fibrosis (Emean median - 5.90 and 7.30 kPa, interquartile range - 5.20-6.75 and 6.20-10.70 kPa, respectively) (P < 0.002). Ultrasound elastography as the non-invasive technology may be used in multiparametric liver assessment in patients with cystic fibrosis, as well as for this patients follow-up.

ультразвуковая эластография, двумерная эластография сдвиговой волной, жесткость, модуль Юнга, муковисцидоз, фиброз, печень, дети, ultrasound elastography, shear wave elastography, stiffness, Young modulus, cystic fibrosis, fibrosis, liver, children

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