Bilateral blood pressure measurement using ultrasound angioscanning and flow spectrogram assessment in the abdominal aorta in an adolescent with secondary arterial hypertension due to previously undiagnosed aortic coarctation
https://doi.org/10.24835/1607-0771-342
Abstract
Aortic coarctation is one of the etiological factors of secondary arterial hypertension. Owing to prenatal diagnostics and modern neonatal screening protocols, in most cases aortic coarctation is identified during the neonatal period. However, according to the literature, in older children and adults aortic coarctation is missed in approximately 85% of cases, even in the presence of such clinical manifestations as heart murmur or arterial hypertension. The article presents a clinical case of an adolescent with newly diagnosed type III aortic coarctation (complete form), complicated by secondary arterial hypertension. Analysis of the literature data and diagnostic errors observed in the patient’s work-up allowed to highlight the following diagnostic approaches that significantly facilitate timely and accurate diagnosis.
1. Bilateral blood pressure measurement at the initial examination of adolescents and adult patients with arterial hypertension, particularly in cases of refractory hypertension and the presence of a cardiac murmur.
2. In situations of technical difficulties in blood pressure measurement by conventional methods (auscultatory, oscillometric, etc.) in the lower extremity arteries, it is recommended to assess systolic pressure by Doppler ultrasound following the method of ankle–brachial index measuring. A simplified approach can be applied by preliminarily assessing the shape of the flow spectrogram.
3. Mandatory screening ultrasound evaluation of the abdominal aorta should be included in the basic protocol of transthoracic echocardiography.
About the Authors
V. A. TemnovaRussian Federation
Valeriуa A. Temnova – MD, PhD, ultrasound diagnostics doctor at the hospital for children, senior researcher, Department of Innovative Diagnostic Research Methods, SRI of Pediatrics and Children`s Health Scientific Clinical Center № 2, Petrovsky Russian Research Center of Surgery, Moscow
https://orcid.org/0009-0002-8895-1849
E-mail: vatemnova@mail.ru
E. A. Zubareva
Russian Federation
Elena A. Zubareva – MD, Doct. of Sci. (Med.), Professor, Head of the Ultrasound Diagnostics Department, Institute of Continuous Education and Professional Development, Pirogov Russian National Research Medical University; ultrasound diagnostics doctor, Federal Scientific and Clinical Center for Children and Adolescents of the Federal Medical and Biological Agency of Russia, Moscow
https://orcid.org/0000-0002-9997-4715
G. V. Revunenkov
Russian Federation
Grigoriy V. Revunenkov – MD, PhD, Radiologist, Head of the Department of Innovative Diagnostic Research Methods, SRI of Pediatrics and Children`s Health Scientific Clinical Center № 2, Petrovsky Russian Research Center of Surgery, Moscow
https://orcid.org/0000-0001-7834-213X
I. V. Zyabkin
Russian Federation
Ilya V. Zyabkin – MD, Doct. of Sci. (Med.), Director of the Federal Scientific and Clinical Center for Children and Adolescents of the Federal Medical and Biological Agency of Russia, Moscow
https://orcid.org/0000-0002-9717-5872
A. V. Krutova
Russian Federation
Alexandra V. Krutova – MD, PhD, Cardiologist, Federal Scientific and Clinical Center for Children and Adolescents of the Federal Medical and Biological Agency of Russia, Moscow
https://orcid.org/0009-0009-8905-5342
S. A. Shtemenko
Russian Federation
Sergey A. Shtemenko – ultrasound diagnostics doctor, Federal Scientific and Clinical Center for Children and Adolescents of the Federal Medical and Biological Agency of Russia, Moscow
https://orcid.org/0009-0003-4046-837X
S. K. Menzelintseva
Russian Federation
Svetlana K. Menzelintseva – Head of the Department of Ultrasound Diagnostics, Federal Scientific and Clinical Center for Children and Adolescents of the Federal Medical and Biological Agency of Russia, Moscow
https://orcid.org/0009-0008-6706-9578
References
1. Alexandrov A.A., Kislyak O.A., Leontieva I.V. Clinical recommendations. Diagnosis, treatment, and prevention of hypertension in children and adolescents. Systemic Hypertension. 2020; 17 (2): 7–35. https://doi.org/10.26442/2075082X.2020 .2.200126 (In Russian)
2. Clinical recommendations of “Aortic coarctation". 2023. https://cr.minzdrav.gov.ru/preview-cr/754_1 (accessed 03/02/2023) (In Russian)
3. Arakelyan V.S., Ivanov A.A., Makarenko V.N. and others. Problems of diagnosis of congenital deformity of the aortic arch. Bulletin of Experimental and Clinical Surgery. 2010; 3 (3): 184–190. (In Russian)
4. Ivanov A.A., Arakelyan V.S. On the classification of congenital deformity of the aortic arch. Fundamental research. 2011; 11 (1): 42–45. (In Russian)
5. Kalmykov E.L., Kalinin R.E., Magamet V.P. et al. Middle aortic syndrome. Bulletin of Surgery. 2016; 175 (6): 104–108. (In Russian)
6. Forman N., Sinskey J., Shalabi A. A Review of Middle Aortic Syndromes in Pediatric Patients. J. Cardiothorac. Vasc. Anesth. 2020; 34 (4): 1042–1050. https://doi.org/10.1053/j.jvca.2019.07.130
7. Kommana S., Wartak S., Joelson J. Coarctation of distal thoracic aorta--the middle aortic syndrome in an elderly female with severe coronary artery disease. J. Invasive Cardiol. 2010; 22 (3): E 47–48.
8. Meng X., Xue J., Cai J. et al. A single-center cohort of mid-aortic syndrome among adults in China: Etiology, presentation and imaging features. Am. J. Med. Sci. 2023; 365 (5): 420–428. https://doi.org/10.1016/j.amjms.2022.04.004
9. Klaydeiter U., Pozza R., Haas N. pediatric echocardiography. Moscow: Medpress-inform, 2022. 420 p. (In Russian)
10. Hoffman JI. The challenge in diagnosing coarctation of the aorta. Cardiovasc. J. Afr. 2018; 29 (4): 252–525. https://doi.org/10.5830/CVJA-2017-053
11. Strafford M.A., Griffiths S.P., Gersony W.M. Coarctation of the aorta: a study in delayed detection. Pediatrics. 1982; 69: 159–163.
12. Ward K.E., Pryor R.W., Matson J.R. et al. Delayed detection of coarctation in infancy: implications for timing of newborn follow-up. Pediatrics. 1990; 86: 972–976.
13. Chetan D., Mertens L. Challenges in diagnosis and management of coarctation of the aorta. Curr. Opin. Cardiol. 2022; 37 (1): 115–122. https://doi.org/10.1097/HCO.0000000000000934
14. Zhernakova Yu.V.1, Rogoza A.N.1, Kislyak O.A. Consensus of experts of the Russian Medical Society for Arterial Hypertension on standardization of measurement of clinical (office) blood pressure. Systemic Hypertension. 2025; 22 (1): 5–11. https://doi.org/10.38109/2075-082X-2025-1-5-11 (In Russian)
15. Hemels M., Hoendermis E., Melle J. et al. Therapy refractory hypertension in adults: aortic coarctation has to be ruled out. Neth. Heart J. 2011; 19 (3): 107–111. https://doi.org/10.1007/s12471-011-0074-8
16. Bokeria E.L., Shumakova O.V., Karavaeva A.L. et al. The effectiveness of neonatal screening for critical congenital heart defects by two-band measurement of systolic blood pressure and saturation. 2024; 23 (6): 13–21. https://doi.org/10.31550/1727-2378-2024-23-6-13-21 (In Russian)
17. Rao P.S. Coarctation of the aorta. Curr. Cardiol. Rep. 2005; 7 (6): 425–434. https://doi.org/10.1007/s11886-005-0060-0
18. Posokhov I.N., Moroz-Vodolazhskaya N.N. “Oscillometric” method: what is it and is it suitable for measuring blood pressure for all patients? Cardiovascular Therapy and Prevention. 2024; 23 (9): 4075. https://doi.org/10.15829/1728-8800-2024-4075 (In Russian)
19. Aboyans V., Criqui M., Abraham P. et al. Measurement and interpretation of the ankle-brachial index: a scientific statement from the American Heart Association. Circulation. 2012; 126 (24): 2890–2909. https://doi.org/10.1161/CIR.0b013e318276fbcb
20. Katz S., Globerman A., Avitzour M., Dolfin T. The ankle-brachial index in normal neonates and infants is significantly lower than in older children and adults. J. Pediatr. Surg. 1997; 32 (2): 269–271. https://doi.org/10.1016/s0022-3468(97)90192-5
21. Métairie A., Tollenaere Q., Lanéelle D. et al. Simplification of ankle-brachial-index measurement using Doppler-waveform classification in symptomatic patients suspected of lower extremity artery disease. Front. Cardiovasc. Med. 2022; 9: 941600. https://doi.org/10.3389/fcvm.2022.941600
22. Ghorbannia A., Ellepola C., Woods R. et al. Clinical, Experimental, and Computational Validation of a New Doppler-Based Index for Coarctation Severity Assessment. J. Am. Soc. Echocardiogr. 2022; 35 (12): 1311–1321. https://doi.org/10.1016/j.echo.2022.09.006
23. Silvilairat S., Cetta F., Biliciler-Denktas G. et al. Abdominal aortic pulsed wave Doppler patterns reliably reflect clinical severity in patients with coarctation of the aorta. Congenit Heart Dis. 2008; 3 (6): 422–430. https://doi.org/10.1111/j.1747-0803.2008.00224.x
24. Houston A.B., Simpson I.A., Pollock J.C. et al. Doppler ultrasound in the assessment of severity of coarctation of the aorta and interruption of the aortic arch. Br. Heart J. 1987; 57 (1): 38–43. https://doi.org/10.1136/hrt.57.1.38
25. Christopher А., Apfel А., Sun Т. et al. Diastolic velocity half time is associated with aortic coarctation gradient at catheterization independent of echocardiographic and clinical blood pressure gradients. Congenit Heart Dis. 2018; 13 (5): 713–720. https://doi.org/10.1097/HCO.0000000000000934
26. Matskeplishvili S.T., Saidova M.A., Mironenko M.Yu. et al. Standard transthoracic echocardiography. Guidelines 2024. Russian Journal of Cardiology. 2025; 30 (2): 6271. https://doi.org/10.15829/1560-4071-2025-6271 (In Russian)
27. Tarzamni M., Nezami N., Ardalan M. et al. Serendipitous diagnosis of aortic coarctation by bilateral parvus et tardus renal Doppler flow pattern. Cardiovasc. Ultrasound. 2007; 5: 44. https://doi.org/10.1186/1476-7120-5-44
Review
For citations:
Temnova V.A., Zubareva E.A., Revunenkov G.V., Zyabkin I.V., Krutova A.V., Shtemenko S.A., Menzelintseva S.K. Bilateral blood pressure measurement using ultrasound angioscanning and flow spectrogram assessment in the abdominal aorta in an adolescent with secondary arterial hypertension due to previously undiagnosed aortic coarctation. Ultrasound & Functional Diagnostics. 2025;31(3):86-96. (In Russ.) https://doi.org/10.24835/1607-0771-342