Uterine hemodynamics in first-trimester pregnant women after treatment of chronic endometritis assessed by ultrasound
https://doi.org/10.24835/1607-0771-348
Abstract
Objective: To evaluate uterine artery blood flow during the first trimester of pregnancy in women with a history of chronic endometritis (CE).
Materials and Methods. A retrospective analysis included 331 pregnant women with previously diagnosed and treated CE. The control group comprised 219 pregnant women with no history of endometrial inflammation. Doppler parameters of uterine artery blood flow were assessed, including the calculation of the uterine arterial perfusion index (UAPI), at 5–7+6, 8–10+6, and 11–13+6 weeks of gestation.
Results. Following CE treatment, no significant increase in blood flow velocities was observed between 5–7+6 and 8–10+6 weeks of gestation; however, a significant increase occurred by 11–13+6 weeks (p < 0.05). In the study group, no decrease in pulsatility index (PI) and resistance index (RI) was observed from week 5 to week 11, but values in both groups became comparable after 11 weeks. Between 5 and 11 weeks of gestation, the UAPI significantly decreased in the CE group and was lower than in controls (p < 0.05). In these patients UAPI increased significantly on first-trimester screening, but remained lower than in the control group. The relative risk of adverse pregnancy outcomes in the CE group was: 3.52 (95% CI: 0.82–15.09) at 5–7+6 weeks, 4.50 (95% CI: 0.59–34.08) at 8–10+6 weeks and 1.49 (95% CI: 0.58–3.84) at 11–13+6 weeks.
Conclusion. Abnormal uterine artery blood flow patterns in women with prior CE may indicate impaired placentation, potentially contributing to adverse pregnancy outcomes.
About the Authors
I. A. Ozerskaya
Peoples' Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
Irina A. Ozerskaya – MD, Doct. of Sci. (Med.), Professor, Professor of the Department of Ultrasound Diagnostics, Faculty of Continuing Medical Education of the Medical Institute, Peoples' Friendship University of Russia named after Patrice Lumumba (RUDN University), Moscow
https://orcid.org/0000-0001-8929-6001
S. Ya. Porkhovaty
LLC "Asklepion"
Russian Federation
Russian Federation
Sergey Ya. Porkhovaty – MD, Cand. of Sci. (Med.), Ultrasound diagnostics doctor, LLC “Asklepion”, Moscow
https://orcid.org/0009-0002-7263-1568
G. G. Kazaryan
LLC "Medskan"
Russian Federation
Russian Federation
Gayane G. Kazaryan – MD, Cand. of Sci. (Med.), Head of the department of ultrasound, LLC “Medskan”, Moscow
https://orcid.org/0000-0002-1198-8187
E. V Ozhogina
Nova Clinic Center for Reproduction and Genetics
Russian Federation
Russian Federation
Ekaterina V. Ozhogina – MD, Cand. of Sci. (Med.), Leading reproductive specialist, Nova Clinic Center for Reproduction and Genetics, Moscow
https://orcid.org/0009-0007-5205-2901
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Review
For citations:
Ozerskaya I.A., Porkhovaty S.Ya., Kazaryan G.G., Ozhogina E.V. Uterine hemodynamics in first-trimester pregnant women after treatment of chronic endometritis assessed by ultrasound. Ultrasound & Functional Diagnostics. 2026;32(1):13-27. (In Russ.) https://doi.org/10.24835/1607-0771-348
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